L-Histidine | High-Performance Essential Amino Acid for Pharmaceutical Applications
L-Histidine is a pharmaceutical-grade essential amino acid widely recognized for its exceptional buffering capacity and protein stabilization properties. This versatile compound serves as a critical excipient in monoclonal antibody formulations, biopharmaceutical manufacturing, and advanced therapeutic applications across biotechnology and pharmaceutical industries.
Product Overview
L-Histidine (CAS 71-00-1) belongs to the essential amino acid family with the molecular formula C₆H₉N₃O₂. This naturally occurring compound features a unique imidazole side chain that provides exceptional buffering properties at physiological pH levels. Our pharmaceutical-grade L-Histidine meets USP, EP, BP, JP, and ChP standards, ensuring consistent quality for critical biopharmaceutical applications. The compound's zwitterionic nature and metal-chelating properties make it indispensable for protein stabilization and formulation development in modern biotechnology.
Key Features & Benefits
- Excellent buffering capacity at pH 7.4, mimicking physiological conditions
- Superior protein stabilization properties for monoclonal antibodies
- Metal ion chelation capabilities preventing oxidative degradation
- Enhanced protein solubility and aggregation prevention
- Multi-compendial compliance (USP/EP/BP/JP/ChP)
- Low endotoxin levels suitable for injectable formulations
- Exceptional thermal and chemical stability
Applications
Biopharmaceutical Manufacturing
L-Histidine serves as the preferred buffering agent in monoclonal antibody formulations, providing optimal pH stability during manufacturing, storage, and transportation. Its unique ability to prevent protein aggregation makes it essential for high-concentration therapeutic protein formulations.
Pharmaceutical Formulations
Used extensively in injectable drug products, vaccine formulations, and protein-based therapeutics where pH control and protein stability are critical. L-Histidine's compatibility with various excipients makes it ideal for complex formulation development.
Research & Development
Essential for cell culture media, protein purification buffers, and analytical method development in biotechnology research. Its consistent performance supports reproducible results in critical research applications.
Technical Specifications
Our L-Histidine exhibits white crystalline powder appearance with high water solubility and excellent stability under standard storage conditions. The product demonstrates optimal buffering range between pH 5.5-7.5 with minimal temperature sensitivity.
For full details, please view our datasheet (TDS).
Comparison & Alternatives
Compared to traditional buffers like phosphate or citrate, L-Histidine offers superior protein compatibility and reduced aggregation risk. While arginine provides similar amino acid benefits, L-Histidine's unique imidazole group delivers enhanced metal chelation and pH stability. L-Histidine HCl variant offers improved solubility characteristics for specific formulation requirements.
FAQ
What is L-Histidine used for?
L-Histidine is primarily used as a buffering agent and protein stabilizer in pharmaceutical formulations, particularly for monoclonal antibodies and biopharmaceutical products.
Is L-Histidine suitable for high-temperature applications?
Yes, L-Histidine demonstrates excellent thermal stability and maintains buffering capacity across typical pharmaceutical processing temperatures.
What's the difference between L-Histidine and L-Histidine HCl?
L-Histidine HCl offers enhanced solubility and is preferred for formulations requiring higher concentrations or specific pH adjustments.
Can L-Histidine be used in injectable formulations?
Absolutely. Our pharmaceutical-grade L-Histidine meets all regulatory requirements for parenteral applications with low endotoxin specifications.
How does L-Histidine compare to other amino acid buffers?
L-Histidine provides superior protein compatibility, metal chelation properties, and optimal buffering range for biological systems compared to other amino acid alternatives.
Contact L-Histidine Supplier Shenzhen Bohr Chem
Ready to enhance your formulation with pharmaceutical-grade L-Histidine? Contact us today for specifications, custom packaging options, or sample requests.
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